MS1943 ( —— )

Catalog No. M21747 CAS No. 2225938-17-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

MS1943
Note

Research use only, not for human use.
Brief Description

MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines.
Description

MS1943 is a first-in-class, orally bioavailable EZH2 selective degrader, with an IC50 of 120 nM. MS1943 significantly reduces EZH2 protein levels in numerous triple-negative breast cancer (TNBC) and other cancer and noncancerous cell lines. MS1943 effectively blocks proliferation of multiple TNBC and other cancer cell lines.
Synonyms

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Pathway

Others
Target

Other Targets
Recptor

——
Research Area

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Indication

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CAS Number

2225938-17-8
Formula Weight

718.93
Molecular Formula

C42H54N8O3
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL (173.87 mM; Need ultrasonic)
SMILES

CC(C)N(N=C1)C2=C1C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C4=CC=C(N=C4)N(CC5)CCN5CCNC(CC67C[C@H]8C[C@H](C[C@H](C8)C7)C6)=O)=C2
Chemical Name

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1. Ma A, et al. Discovery of a first-in-class EZH2 selective degrader.Nat Chem Biol. 2020 Feb;16(2):214-222.

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